• Although NO may act as the substrate for NO biosynthesis

  2022-02-22

  

  Although, NO2− may act as the substrate for NO biosynthesis no strict correlation between NO2− fluctuation in roots and NO content was observed in tomato roots. As the culture period was prolonged NO2− concentration declined in control and m-Tyr exposed seedlings, and finally its concentration was s

• To facilitate the development of novel diagnostic and therap

  2022-02-22

  

  To facilitate the development of novel diagnostic and therapeutic interventions in NASH, a plethora of animal models have been used to identify molecular targets that are involved in the onset and progression of NASH. In view of recent advances in the understanding of the pathogenesis of NASH and pr

• Considering that loss of LAG

  2022-02-22

  

  Considering that loss of LAG-3 atrial natriuretic peptide receptor results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indica

• The synthesis of is shown in

  2022-02-22

  

  The synthesis of is shown in . The ---Boc--diaminopropanoic acid--butyl ester () fragment was synthesized in four steps from Boc--asparagine (). The key step in this synthesis was a Hofmann rearrangement of the terminal carboxamide, which was performed according to the elegant protocol of Zhang tha

• Our overall goal is to develop selective

  2022-02-22

  

  Our overall goal is to develop selective compounds for low-affinity/high-capacity transporters inhibitors (i.e. OCT1–3 and PMAT), and provide the field with much needed, specific pharmacological tools to study these transporters. In our initial efforts, we synthesized halogen substituted analogs and

• Acarbose and voglibose the classic

  2022-02-22

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• We report on four affected children from

  2022-02-22

  

  We report on four affected children from two unrelated consanguineous TNKS 22 with moderate to severe ID associated with epilepsy and variable neuropsychiatric features. Using whole-exome sequencing, we identified homozygous missense variants in SLC45A1 (OMIM: 605763), which codes for a neuronal gl

• In conclusion we have shown that AKR D regulates

  2022-02-22

  

  In conclusion, we have shown that AKR1D1 regulates glucocorticoid availability and GR activation and therefore represents a key pre-receptor regulator of hormonal action in human liver. However, there are additional questions that need to be addressed including dissecting the broader role of AKR1D1

• br Discussion RBCs possess a much simpler

  2022-02-22

  

  Discussion RBCs possess a much simpler composition and structure than other eukaryotic Thymidine australia and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in this

• br Financial support This work was supported by Fondation

  2022-02-21

  

  Financial support This work was supported by Fondation pour la Recherche Médicale (Equipe labellisée, DEQ20150331724), Inserm, University of Lille, and Agence Nationale pour la Recherche (ANR-10-LBEX-46 and ANR-10-INBS-08; ProFI project, “Infrastructures Nationales en Biologie et Santé”; “Investi

• To evaluate the role of increased FPPS expression in paclita

  2022-02-21

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on Triamcinolone receptor progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cel

• Introduction of a chloropyridine group onto the fluoro deriv

  2022-02-21

  

  Introduction of a chloropyridine group onto the fluoro derivative (→) leads to a similarly potent compound that exhibits a lower /, and as was observed with (), was rapidly cleared. However, the high clearance of () did not prevent the increase in the concentrations of FAAs even as its plasma levels

• The study by Pigna and collaborators

  2022-02-21

  

  The study by Pigna and collaborators provides an elegant demonstration why class IIa HDAC inhibition may not be suitable to protect the neuromuscular function in ALS, consistent with a recent study that showed only a transient protection of motor performance after treatment of the same ALS model wit

• n oxide In an attempt to further optimize interactions in th

  2022-02-21

  

  In an attempt to further optimize interactions in the lipophilic P4 pocket, we next prepared compounds – () which possessed the preferred stereochemistry at P4, but with R-groups of varying size and shape. In addition to providing important structural information for maximizing potency, these compou

• br Molecular mechanisms underpinning GSNOR function in the d

  2022-02-21

  

  Molecular mechanisms underpinning GSNOR1 function in the defence response Recently, Arabidopsis GSNOR1 has been shown to govern the extent of S-nitrosylation of two key regulatory proteins, Non-Expresser of Pathogenesis-Related Genes 1 (NPR1) and SA binding protein 3 (SABP3), which are integral t

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